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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Pregnancy in systemic lupus erythematosus.
Dina Zucchi1, Rebecca Fischer-Betz2, Chiara Tani3
1Rheumatology Unit, Azienda Ospedaliero Universitaria Pisana and Department of Clinical and Experimental Medicine, University of Pisa, Italy; Department of Medical Biotechnologies, University of Siena, Italy.
Best Practice & Research. Clinical Rheumatology
|August 18, 2023
Summary
Systemic lupus erythematosus (SLE) in pregnant women carries risks, but well-controlled disease allows for safer pregnancies. Close monitoring and preconception care are vital for better maternal and fetal outcomes in SLE patients.
Area of Science:
- Rheumatology
- Obstetrics
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune condition predominantly affecting women of childbearing age.
- While pregnancy is feasible with well-controlled SLE, these pregnancies face elevated risks of maternal and fetal complications.
- Disease flares and obstetric issues are more common with active disease at conception, prior lupus nephritis, or coexisting antiphospholipid syndrome.
Purpose of the Study:
- To review risk factors associated with adverse pregnancy outcomes in SLE patients.
- To provide an updated overview of medical management strategies for pregnant individuals with SLE.
Main Methods:
- Literature review focusing on risk factors and management of pregnancy in SLE.
- Synthesis of current evidence on preconception counseling and monitoring.
Main Results:
- Active disease at conception, history of lupus nephritis, and antiphospholipid syndrome are key risk factors for poor outcomes.
- Preconception counseling and medication adjustment are crucial.
- Continuous rheumatological and obstetrical monitoring significantly impacts pregnancy success.
Conclusions:
- Improved pregnancy outcomes in SLE patients necessitate proactive preconception planning and diligent monitoring.
- Advances in medical care offer better management options for SLE during pregnancy.
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