Normative brain mapping using scalp EEG and potential clinical application.

Area of Science:

• Neuroscience
• Biomedical Engineering
• Medical Imaging

Background:

• Understanding normal brain function is crucial for identifying neurological disorders.
• Electroencephalography (EEG) provides valuable insights into brain dynamics.
• Normative brain maps can serve as a reference for assessing brain activity.

Purpose of the Study:

• To create a normative brain map using scalp EEG relative band power.
• To assess the temporal stability and cross-modality similarity of these maps.
• To explore the clinical utility of normative EEG maps in epilepsy.

Main Methods:

• Constructed scalp EEG normative maps from 17 healthy controls using source-localized resting-state recordings.
• Correlated EEG maps with Magnetoencephalography (MEG) and intracranial EEG (iEEG) data.
• Applied normative maps to lateralize abnormal brain regions in epilepsy patients.

Main Results:

• Spatial patterns of band powers were consistent with existing literature and temporally stable.
• Scalp EEG maps showed highest similarity to MEG and iEEG in the alpha band.
• Abnormal temporal regions were identified ipsilateral to the epileptogenic hemisphere in epilepsy cases.

Conclusions:

• Scalp EEG relative band power normative maps are spatially stable and feasible to create.
• Normative mapping demonstrates potential clinical utility, especially in epilepsy diagnosis and localization.
• Further validation with larger cohorts and high-density EEG is recommended.