Amyloidosis in a dog: treatment with dimethylsulfoxide

A dog with hypoalbuminemia, proteinuria, and renal amyloidosis was treated with dimethylsulfoxide for 2 years. During a 1-year period, serum albumin concentrations increased to within normal range. The 24-hour urinary protein excretion was 5.7 g before treatment with dimethylsulfoxide. Two years after initiation of treatment, the 24-hour urinary protein excretion was 3.7 g. Removal of a testicle containing a Sertoli cell tumor and treatment of interdigital pyoderma may have been factors in the dog's clinical improvement. The only adverse effect from the dimethylsulfoxide treatment was the characteristic disagreeable odor.