rBahadur: efficient simulation of structured high-dimensional genotype data with applications to assortative mating
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Updated: Sep 30, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Richard Border1, Osman Asif Malik2
1Neurology and Computer Science, University of California, Los Angeles, 675 Charles E Young Dr S, Los Angeles, CA, 90095, USA. border.richard@gmail.com.
Abstract:
Existing methods for generating synthetic genotype data are ill-suited for replicating the effects of assortative mating (AM). We propose rb_dplr, a novel and computationally efficient algorithm for generating high-dimensional binary random variates that effectively recapitulates AM-induced genetic architectures using the Bahadur order-2 approximation of the multivariate Bernoulli distribution. The rBahadur R library is available through the Comprehensive R Archive Network at https://CRAN.R-project.org/package=rBahadur .
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