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Glasgow prognostic score as an outcome predictor for patients initiating hemodialysis

Gabriel Ștefan1,2, Adrian Zugravu1,2, Simona Stancu1,2

  • 1Nephrology Department, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|August 19, 2023
PubMed

Insights

The Glasgow Prognostic Score (GPS) at hemodialysis (HD) initiation is linked to patient mortality. Higher GPS scores indicate increased mortality risk, suggesting its use as a prognostic tool for high-risk hemodialysis patients.

Area of Science:

  • Nephrology
  • Clinical Medicine
  • Prognostics

Background:

  • The Glasgow Prognostic Score (GPS) is a marker of systemic inflammation.
  • Its utility in predicting outcomes for patients initiating hemodialysis (HD) requires further investigation.

Purpose of the Study:

  • To examine the association between the Glasgow Prognostic Score (GPS) at hemodialysis (HD) initiation and overall and cardiovascular mortality.
  • To evaluate GPS as a prognostic indicator in patients commencing HD therapy.

Main Methods:

  • Retrospective analysis of 264 patients initiating HD between 2014-2015.
  • Follow-up until December 31, 2021, with a median duration of 6.8 years.
  • Utilized Cox proportional hazard models to assess mortality risk.

Main Results:

  • Higher GPS scores were associated with emergent HD initiation and increased eGFR at initiation.
  • 60% of patients experienced mortality during follow-up, with cardiovascular disease as the primary cause.
  • Significant differences in median survival time were observed across GPS classes, confirming GPS as a predictor of mortality.

Conclusions:

  • A significant association exists between GPS at HD initiation and patient mortality.
  • GPS demonstrates potential as a prognostic tool for identifying high-risk hemodialysis patients.
  • Further research is warranted to validate these findings and explore GPS-based interventions.
Abstract

Keywords:
Glasgow prognostic scorecardiovascular mortalityend-stage kidney diseasehemodialysis initiationsurvival analysis

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