Related Experiment Video

Updated: Jul 18, 2025

CO2-Lasertonsillotomy Under Local Anesthesia in Adults
05:07

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

Published on: November 6, 2019

24.5K

Management of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis with Intracapsular Tonsillectomy

Uche C Ezeh1, Philip J Kahn2, Max M April1

  • 1Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, New York, U.S.A.

The Laryngoscope
|August 19, 2023
PubMed

Insights

Intracapsular tonsillectomy with adenoidectomy (ITA) effectively treated pediatric patients with periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome, resolving symptoms without complications.

Area of Science:

  • Otolaryngology
  • Pediatric Surgery
  • Immunology

Background:

  • Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is a common autoinflammatory disorder in children.
  • Surgical intervention, specifically tonsillectomy, is a recognized treatment for refractory PFAPA syndrome.
  • Intracapsular tonsillectomy with adenoidectomy (ITA) offers a potentially less invasive surgical approach compared to total tonsillectomy.

Observation:

  • This study retrospectively analyzed 2 pediatric patients diagnosed with PFAPA syndrome.
  • Both patients presented with recurrent febrile episodes and were candidates for surgical management.
  • ITA was performed using a microdebrider, with close postoperative follow-up.

Findings:

  • The ITA procedure was highly efficacious in both pediatric patients.
  • Neither patient experienced postoperative complications.
  • Symptomatic resolution of PFAPA was sustained for over 1 year post-surgery in both cases.

Implications:

  • ITA represents a safe and effective surgical treatment option for PFAPA syndrome in children.
  • This minimally invasive approach may reduce the risks associated with total tonsillectomy.
  • Further research with larger cohorts and longer follow-up periods is warranted to validate ITA as a standard treatment for PFAPA.
Abstract

Keywords:
PFAPA syndromeintracapsular tonsillectomytotal tonsillectomy

More Related Videos

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue07:38

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue

Published on: June 14, 2020

7.5K
Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils08:09

Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils

Published on: November 16, 2015

15.9K

Related Concept Videos

Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
2.7K
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
134
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
306
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
831
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
13
Pharynx01:20

Pharynx

The pharynx, a tubular structure framed by skeletal muscle and lined with mucous membrane, extends continuously from the nasal cavities. It is segmented into three major areas: the nasopharynx, oropharynx, and laryngopharynx.
Nasopharynx
The nasopharynx, bordered by the conchae of the nasal cavity, serves exclusively as an air conduit. In its superior region, the pharyngeal tonsils or adenoids are located. These tonsils are clusters of lymphoid reticular tissue akin to a lymph node. The precise...
1.9K