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Area of Science:

  • Nuclear physics
  • Radiopharmaceutical science
  • Metrology

Background:

  • Lutetium-177 (¹⁷⁷Lu) is a key therapeutic radiopharmaceutical.
  • Accurate standardization is essential for its safe and effective clinical application.
  • ¹⁷⁷Lu decays via beta, gamma, and electron emissions, complicating standardization.

Purpose of the Study:

  • To standardize a ¹⁷⁷Lu solution for use in Switzerland.
  • To compare the results obtained from beta-gamma coincidence counting and the triple-to-double coincidence ratio (TDCR) method.
  • To assess the presence of any ¹⁷⁷Lu impurities.

Main Methods:

  • Standardization using the beta-gamma coincidence technique with analogue and digital electronics.
  • Standardization using the triple-to-double coincidence ratio (TDCR) method.
  • Monte Carlo simulations for detection efficiency calculations.

Main Results:

  • The standardized ¹⁷⁷Lu solution was found to be free of ¹⁷⁷Lu impurity.
  • Beta-gamma coincidence measurements (analogue and digital) were consistent with each other.
  • Discrepancies were observed between the beta-gamma coincidence results and the TDCR measurements.

Conclusions:

  • While beta-gamma coincidence methods yielded compatible results, they differed from TDCR measurements.
  • Further investigation is needed to resolve the discrepancies between the applied standardization techniques.
  • The standardized ¹⁷⁷Lu solution was submitted to the BIPM for international comparison.