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Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation

Chang Zhao1, Heli Wang1, Ying Liu2

  • 1Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China.

Molecular Cell
|August 19, 2023
PubMed

Keywords:
BHBGPCRHCAR2allosteric modulationanti-inflamationbiased allosteric modulatorcryo-EMketone body receptorniacinstructural biology

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