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Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

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Long-acting microneedle formulations.

Lalitkumar K Vora¹, Akmal H Sabri¹, Yara Naser¹

¹School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.

Advanced Drug Delivery Reviews

|August 19, 2023

Summary

This summary is machine-generated.

Microneedle (MN) patches offer a painless alternative to injections for long-acting drug delivery. This review explores MN designs and formulations for sustained therapeutic release, aiming to improve patient compliance and treatment outcomes.

Keywords:

Controlled release Intradermal route Long-acting drug delivery Microneedles Ocular delivery Sustained release Transdermal route

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Area of Science:

Biomaterials Science
Drug Delivery Systems
Nanotechnology

Background:

Microneedles (MNs) provide a minimally-invasive alternative to traditional injections, addressing challenges in dermal and ocular drug administration.
Various MN designs, including dissolving, polymeric, hollow, and hydrogel types, facilitate controlled and prolonged release of therapeutic payloads.
These advanced delivery platforms enhance patient compliance by reducing administration frequency and side effects.

Purpose of the Study:

To review microneedle (MN) formulations designed for long-acting drug delivery across diverse diseases.
To highlight critical design aspects, including polymer selection, MN geometry, and computational modeling, for translational success.
To discuss manufacturing, regulatory considerations, and future research directions for MN technology.

Main Methods:

Literature review of microneedle (MN) formulations for sustained drug delivery.
Analysis of MN design parameters, material selection, and fabrication techniques.
Examination of computational modeling, manufacturing scalability, and regulatory pathways.

Main Results:

Diverse MN types (dissolving, polymeric, hollow, hydrogel) enable controlled, long-acting therapeutic delivery.
Optimized MN design and material selection are crucial for achieving desired release profiles and clinical impact.
Computational modeling aids in streamlining MN development for enhanced translational value.

Conclusions:

Microneedle technology offers an elegant, painless solution for sustained drug delivery, potentially improving patient compliance.
Judicious material selection and refined design are key to realizing the full clinical potential of MN patches.
Addressing manufacturing and regulatory hurdles is essential for bringing advanced MN drug delivery systems to market.