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Endurance exercise training reduces lactate production.

R J Favier, S H Constable, M Chen

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |September 1, 1986
    PubMed
    Summary
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    Endurance exercise training reduces lactate production in contracting muscles of rats. This adaptation is linked to better glycogen sparing during muscle activity.

    Area of Science:

    • Exercise Physiology
    • Muscle Metabolism
    • Biochemistry

    Background:

    • Endurance exercise training is known to induce significant physiological adaptations in skeletal muscle.
    • A key question is whether these adaptations alter the metabolic response to contractile activity, specifically lactate production.

    Purpose of the Study:

    • To investigate if endurance training adaptations lead to decreased lactate production in contracting muscles.
    • To examine the relationship between glycogen sparing and reduced lactate accumulation.

    Main Methods:

    • In situ stimulation of the gastrocnemius-plantaris-soleus muscle group in trained and untrained rats.
    • Measurement of lactate and glycogen concentrations in different muscle fiber types after 3 minutes of controlled isotonic contractions.

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    Main Results:

    • Trained rats exhibited approximately 50% lower increases in lactate concentration in slow-twitch and fast-twitch red muscles compared to sedentary rats.
    • A 28% reduction in lactate increase was observed in the fast-twitch white portion of the gastrocnemius in trained rats.
    • Muscle glycogen depletion was significantly less in trained rats, correlating with reduced lactate accumulation.

    Conclusions:

    • Endurance training induces adaptations that result in slower lactate production by skeletal muscle during contractile activity.
    • Glycogen sparing is a significant factor contributing to the reduced lactate accumulation observed post-training.