Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules.

Science (New York, N.Y.)·2024

Same author

Genetic complexity of diagnostically unresolved Ehlers-Danlos syndrome.

Journal of medical genetics·2023

Same author

Students' and staffs' views and experiences of asymptomatic testing on a university campus during the COVID-19 pandemic in Scotland: a mixed methods study.

BMJ open·2023

Same author

Genome sequencing with gene panel-based analysis for rare inherited conditions in a publicly funded healthcare system: implications for future testing.

European journal of human genetics : EJHG·2022

Same author

Docetaxel for Nonmetastatic Prostate Cancer: Long-Term Survival Outcomes in the STAMPEDE Randomized Controlled Trial.

JNCI cancer spectrum·2022

Same author

Fast and automated biomarker detection in breath samples with machine learning.

PloS one·2022

Same journal

The concept of functional cure in advanced/metastatic melanoma treated with combined nivolumab and ipilimumab or nivolumab alone.

British journal of cancer·2026

Same journal

Efficacy and safety of a novel oral anti-vasculogenic mimicry agent, CVM-1118, in advanced well-differentiated neuroendocrine tumors: a Phase IIa trial.

British journal of cancer·2026

Same journal

Altretamine induces ferroptosis in small cell lung cancer by promoting epigenetic silencing and lysosomal degradation of GPX4.

British journal of cancer·2026

Same journal

Revisiting retinoic acid in AML therapy: mechanisms of action and rational combination strategies.

British journal of cancer·2026

Same journal

De novo cancer-related mortality after solid organ transplantation in England: the EpCOT study.

British journal of cancer·2026

Same journal

Planetary Health Diet Index and breast cancer risk.

British journal of cancer·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 18, 2025

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

Redefining precision radiotherapy through liquid biopsy.

D B McLaren¹, T J Aitman²

¹Edinburgh Cancer Centre, Western General Hospital, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XU, UK. duncan.mclaren@ed.ac.uk.

British Journal of Cancer

|August 19, 2023

Summary

This summary is machine-generated.

Precision radiotherapy improves accuracy but not outcomes. Analyzing cell-free DNA for personalized dosing alongside precise delivery will redefine radiotherapy precision for better tumor control and reduced toxicity.

More Related Videos

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

Related Experiment Videos

Last Updated: Jul 18, 2025

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

Area of Science:

Radiation oncology
Molecular diagnostics
Cancer treatment

Background:

Precision radiotherapy delivers radiation with sub-millimetre accuracy.
Current methods do not account for individual variations in tumor or normal tissue response.
This limitation hinders maximal tumor control and optimal toxicity minimization.

Purpose of the Study:

To propose a redefined approach to precision radiotherapy.
To integrate personalized dosing based on cell-free DNA analysis with precise radiation delivery.
To enhance radiotherapy's effectiveness in maximizing tumor control and minimizing toxicity.

Main Methods:

Review of current precision radiotherapy techniques.
Exploration of cell-free DNA analysis for personalized dosing strategies.
Conceptual integration of precise delivery and personalized dosing.

Main Results:

Precision radiotherapy's accuracy is established but insufficient for optimal outcomes.
Cell-free DNA analysis offers a viable method for assessing individual treatment response.
Combining precise delivery with personalized dosing presents a novel paradigm.

Conclusions:

Redefining precision radiotherapy requires integrating personalized dosing with accurate delivery.
Cell-free DNA analysis is a key biomarker for personalized radiotherapy.
This integrated approach promises to significantly improve cancer treatment efficacy and patient safety.