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Imaging of cell death in malignancy: Targeting pathways or phenotypes?
1Department of Nuclear Medicine and PET, Prince of Wales Hospital, Sydney, Australia; School of Clinical Medicine, UNSW Medicine & Health, Randwick Clinical Campus, UNSW Sydney, Australia.
Nuclear Medicine and Biology
|August 20, 2023
Summary
Directly imaging cancer cell death offers personalized treatment. This review explores radiopharmaceuticals targeting cell death pathways or phenotypes for improved cancer therapy response assessment.
Area of Science:
- Oncology
- Medical Imaging
- Radiochemistry
Background:
- Cell death is crucial in cancer, yet current imaging methods indirectly assess treatment response.
- Existing techniques like CT and FDG-PET lack specificity and timeliness for direct cell death visualization.
- Developing direct cancer cell death imaging is vital for personalized, adaptive cancer therapies.
Conclusions:
- Direct imaging of cancer cell death is achievable through various targeting strategies.
- Phenotype-agnostic imaging holds promise for broader applicability in assessing treatment response.
- Further development of radiopharmaceuticals is needed to enable timely and accurate personalized cancer treatment.
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