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Nod-like receptors in inflammatory arthritis
Sahib Singh Madahar1, Alita Gideon2, Ali A Abdul-Sater2
1School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada; Department of Biology, York University, Toronto, Ontario, Canada.
Biomedical Journal
|August 20, 2023
Summary
Nod-like receptors (NLRs) are key in sensing danger signals and driving inflammatory arthritis (IA). This review explores NLRs
Area of Science:
- Immunology and Molecular Biology
- Innate Immunity and Inflammatory Diseases
Background:
- Nod-like receptors (NLRs) are critical innate immune sensors detecting pathogen and danger signals.
- NLRs form inflammasome complexes, activating inflammatory pathways and transcription factors.
- Inflammatory arthritis (IA) encompasses conditions like rheumatoid arthritis (RA), psoriatic arthritis (PsA), and pediatric arthritis.
Purpose of the Study:
- To review the role of NLRs in the pathogenesis of inflammatory arthritis (IA).
- To examine the evidence for and against specific NLR involvement in IA.
- To discuss the therapeutic potential of NLR and inflammasome inhibitors for IA.
Main Methods:
- Literature review of studies on NLRs and inflammatory arthritis.
- Analysis of evidence implicating specific NLRs in IA pathogenesis.
- Review of clinical and preclinical studies on NLR/inflammasome inhibitors.
Main Results:
- NLRs are increasingly recognized as significant drivers of IA pathogenesis.
- Evidence supports the involvement of specific NLRs in various IA subtypes.
- NLR and inflammasome inhibitors show promise as potential IA therapies.
Conclusions:
- NLRs play a crucial role in the inflammatory processes underlying IA.
- Targeting NLRs and inflammasomes represents a promising therapeutic strategy for IA.
- Further research is warranted to fully elucidate NLR functions and optimize inhibitor therapies.
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