SARS-CoV-2 infection during pregnancy - single-center retrospective study
Malgorzata Skalska-Swistek1, Magdalena Kolak2, Andrzej P Jaworowski2
1Department of Obstetrics & Perinatology, Jagiellonian University Medical College, Cracow, Poland, Poland. malgorzata12.skalska@uj.edu.pl.
Ginekologia Polska
|August 21, 2023
Summary
COVID-19 significantly impacts pregnant patients, with nearly 20% experiencing respiratory failure and requiring intensive care. However, vertical transmission of SARS-CoV-2 to newborns was not confirmed in this study.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Critical Care Medicine
Background:
- The global spread of SARS-CoV-2 presents unique challenges in managing pregnant patients.
- COVID-19 in pregnancy requires careful evaluation of maternal and fetal outcomes.
- Understanding the clinical course and treatment of pregnant women with COVID-19 is crucial.
Purpose of the Study:
- To evaluate obstetric outcomes in pregnant patients with COVID-19.
- To analyze biochemical markers in pregnant patients diagnosed with SARS-CoV-2.
- To assess the treatment strategies employed for pregnant women affected by COVID-19.
Main Methods:
- Retrospective analysis of 146 pregnant patients hospitalized with COVID-19.
- Data collected from July 2020 to August 2021 at Jagiellonian University Medical College.
- Inclusion of obstetric, biochemical, and treatment data.
Main Results:
- Respiratory failure occurred in 19.19% of cases, with 16.6% requiring ICU transfer and intubation.
- Mild symptoms including asymptomatic cases (39.04%), cough (41.78%), dyspnea (30.82%), and myalgia (23.97%) were common.
- Elevated CRP and IL-6, decreased total protein, and increased d-dimers were observed. Prophylactic heparin was administered to 98.63% of patients.
- Cesarean sections were performed in 59.59% of cases, with newborns in good condition. No vertical SARS-CoV-2 transmission was confirmed.
Conclusions:
- COVID-19 has a significant impact on pregnant patients, notably increasing the risk of respiratory failure.
- A substantial proportion of affected pregnant women required intensive care and mechanical ventilation.
- While maternal outcomes can be severe, newborns generally presented in good condition, and vertical transmission was not detected.
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