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Berberine influences multiple diseases by modifying gut microbiota.

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Berberine (BBR), a plant alkaloid, impacts diseases by interacting with gut microbiota. This review details BBR

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Area of Science:

  • Pharmacology and Microbiology
  • Natural Products Research
  • Gut Microbiome Studies

Background:

  • Berberine (BBR) is a plant-derived isoquinoline alkaloid with therapeutic potential.
  • BBR exhibits low oral bioavailability but significantly interacts with the gut microbiota.
  • Gut microbiota modulation by BBR is implicated in various disease pathologies.

Purpose of the Study:

  • To systematically review the interactions between Berberine and gut microbiota.
  • To elucidate the effects of BBR on diverse diseases through the lens of gut microbiota.
  • To analyze BBR-induced gut microbiota alterations and their clinical implications.

Main Methods:

  • Comprehensive literature search on Berberine, gut microbiota, and disease.
  • Systematic review and synthesis of existing research findings.
  • Analysis of studies reporting changes in gut microbiota composition and function following BBR intervention.

Main Results:

  • Berberine's therapeutic effects in diabetes, hyperlipidemia, atherosclerosis, liver, intestinal, mental, and autoimmune diseases are linked to its gut microbiota interactions.
  • Different doses of BBR induce distinct changes in gut microbiota profiles.
  • These microbial shifts correlate with observed clinical outcomes.

Conclusions:

  • Berberine's clinical efficacy is significantly mediated by its modulation of the gut microbiome.
  • Understanding these interactions is crucial for optimizing BBR's therapeutic application.
  • Further research can guide the rational clinical use of Berberine based on its gut microbiota effects.