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Updated: Jul 18, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
28.3K
Association between gut microbiota and psychiatric disorders: a systematic review
Carmen Grau-Del Valle1, Javier Fernández1, Eva Solá1,2
1Department of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain.
Frontiers in Psychology
|August 21, 2023
Summary
Gut microbiota dysbiosis is linked to various pathologies, including mood and neuropsychiatric disorders. Altered gut bacteria composition correlates with conditions like depression, anxiety, and autism spectrum disorder (ASD).
Area of Science:
- Neuroscience
- Microbiology
- Psychiatry
Background:
- Intestinal microbiota dysbiosis is increasingly recognized for its role in various pathologies.
- A bidirectional communication exists within the gut-brain axis, linking gut microbiota to brain function and mood disorders.
Approach:
- A systematic review of 18 human studies published within the last 11 years was conducted.
- Studies were sourced from PubMed and Scopus, adhering to PRISMA guidelines and assessed for quality using CASP.
- The review focused on original studies with a control group.
Key Points:
- Psychiatric disorders are associated with distinct alterations in gut bacterial phyla.
- Significant differences in gut microbiota composition are observed between individuals with psychiatric disorders and healthy controls.
- The gut microbiota composition is clearly related to depression, stress, autism spectrum disorder (ASD), psychotic episodes, eating disorders, and anxiety.
Conclusions:
- A reduction in fermentative bacteria and short-chain fatty acid (SCFA) production is noted in psychiatric disorders.
- An increase in pro-inflammatory taxa is observed, potentially exacerbating these pathological conditions.
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