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Published on: February 3, 2023
Oral disintegration films: applications and production methods
Simone Canabarro Palezi1, Sibele Santos Fernandes1, Vilásia Guimarães Martins1
1School of Chemistry and Food Engineering, Federal University of Rio Grande (FURG), Avenida Itália km 8, Carreiros, Rio Grande, RS 96203900 Brazil.
Orally disintegrating films (ODF) offer a patient-friendly alternative to traditional tablets for delivering active compounds. This review highlights recent advancements, applications, and production methods for ODFs.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Orally disintegrating films (ODF) are gaining prominence as advanced drug delivery systems.
- They offer significant advantages over conventional oral tablets, including ease of administration without water and improved patient compliance.
- ODFs are particularly beneficial for individuals experiencing dysphagia (difficulty swallowing).
Purpose of the Study:
- To review recent advancements in orally disintegrating films (ODF).
- To explore the diverse applications of ODFs in delivering various active compounds.
- To present and discuss the primary production methodologies for ODFs.
Main Methods:
- Review of current literature on ODF technology.
- Analysis of polymer science in film formulation.
- Examination of manufacturing techniques like solvent evaporation and hot extrusion.
Main Results:
- ODFs utilize polymers, plasticizers, and active compounds, with polymer choice critically impacting disintegration and release kinetics.
- Key production methods include solvent evaporation and hot extrusion, though scalability presents challenges.
- Recent developments show ODFs effectively carrying natural compounds with antioxidant and antimicrobial properties.
Conclusions:
- Orally disintegrating films represent a significant and innovative alternative for active compound delivery.
- Their unique properties enhance patient comfort and therapeutic efficacy.
- Continued research and development in ODF technology are warranted due to growing interest and potential applications.
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