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Global Trends and Hotspots on Microglia Associated with Pain from 2002 to 2022: A Bibliometric Analysis
Guoqi Dong1, Hui Li1, Hui Gao1
1School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Background:
Researchers have made significant progress in microglia associated with pain in recent years. However, more relevant bibliometric analyses are still needed on trends and directions in this field. The aim of this study is to provide a comprehensive perspective and to predict future directions of pain-related microglia research via bibliometric tools.
Methods:
English articles and reviews related with pain and microglia were extracted from the Web of Science core collection (WosCC) database between 2002 to 2022. Bibliometric tools such as VOSviewer, CiteSpace, and Bibliometrix R package were used to analyze publication characteristics, countries, authors, institutions, journals, research hotspots, and trend topics.
Results:
A total of 2761 articles were included in this analysis. Research on microglia associated with pain has increased significantly over the last two decades. China (n = 1020, 36.94%) and the United States (n = 751, 27.20%) contributed the most in terms of publications and citations, respectively. Kyushu University published the most articles in this field compared to other institutions, and Professor Inoue Kazuhide (n = 54) at this university made outstanding contributions in this field. Molecular Pain (n = 113) was the journal with the most publication, while Journal of Neuroscience had the highest number of citations. According to the authors keywords analysis, the research in this area can be summarized into 7 clusters such as "microglia activation pathways", "pain treatment research", "mental symptoms of chronic pain", and so on.
Conclusion:
This study provides a comprehensive analysis of pain-related microglia research in the past two decades. We identified the countries, institutions, scholars, and journals with the highest number of publications and the most influence in the field, and the research trends identified in this paper may provide new insights for future research.
Insights
Recent bibliometric analysis reveals a significant increase in pain and microglia research over two decades. China and the US lead publications, with key institutions and authors identified, highlighting emerging research hotspots in microglia activation and pain treatment.
Area of Science:
- Neuroscience
- Immunology
- Pain Research
Background:
- Microglia play a crucial role in pain mechanisms.
- Significant advancements have been made in understanding microglia's involvement in pain.
- Bibliometric analyses are essential for tracking trends and future directions in this field.
Purpose of the Study:
- To provide a comprehensive bibliometric analysis of pain-related microglia research.
- To identify key contributors, influential publications, and emerging research hotspots.
- To predict future research directions in pain and microglia.
Main Methods:
- Bibliometric analysis of 2761 English articles and reviews from 2002-2022.
- Data extracted from the Web of Science core collection (WosCC).
- Analysis using VOSviewer, CiteSpace, and Bibliometrix R package.
Main Results:
- Research output has significantly increased over the past two decades.
- China and the United States are leading countries in publications and citations.
- Kyushu University and Professor Inoue Kazuhide are notable contributors; Molecular Pain and Journal of Neuroscience are key journals.
- Identified research clusters include microglia activation pathways, pain treatment, and mental symptoms of chronic pain.
Conclusions:
- This study offers a comprehensive overview of pain-related microglia research over the last 20 years.
- Identified key countries, institutions, authors, and journals shaping the field.
- The identified trends provide valuable insights for future research directions in pain and microglia.
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