Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis and dynamic modeling of firing synchronization in electrically interconnected dual-compartment neuronal networks.

Microsystems & nanoengineering·2026
Same author

State-dependent neuronal and network dynamics in the lateral hypothalamus across sevoflurane anesthesia-emergence revealed by microelectrode arrays.

Microsystems & nanoengineering·2026
Same author

Orthosteric and allosteric effects of anti-CRISPR II-C1 inhibition on <i>Geo</i> Cas9 from integrated structural biophysics.

bioRxiv : the preprint server for biology·2026
Same author

In Vitro Biological Neuronal Networks Achieve Low-Power Consumption and High-Speed Communication through Predictable Stimulation.

ACS sensors·2026
Same author

From Physical Replacement to Biological Symbiosis: Evolutionary Paradigms and Future Prospects of Auditory Reconstruction Brain-Computer Interfaces.

Micromachines·2026
Same author

Highly mechanically stable PEDOT:PSS/PDA-modified microelectrode arrays reveal state-specific dynamic neural activity across sleep-wake.

Microsystems & nanoengineering·2026

Related Experiment Video

Updated: Jul 18, 2025

Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays
07:51

Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays

Published on: October 19, 2016

9.9K

Exploring retinal ganglion cells encoding to multi-modal stimulation using 3D microelectrodes arrays.

Kui Zhang1,2, Yaoyao Liu1,2, Yilin Song1,2

  • 1State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China.

Frontiers in Bioengineering and Biotechnology
|August 21, 2023
PubMed
Summary

Researchers developed a novel 3D microelectrode array (MEA) to improve recordings of retinal ganglion cells (RGCs). This advanced MEA enhances signal quality and enables detailed investigation of neural encoding under multi-modal stimulation.

Keywords:
3D microelectrodes arrayselectroplatingmulti-modal stimulationneural encodingretinal ganglion cells

More Related Videos

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

3.8K
Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
08:28

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

1.1K

Related Experiment Videos

Last Updated: Jul 18, 2025

Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays
07:51

Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays

Published on: October 19, 2016

9.9K
Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

3.8K
Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
08:28

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

1.1K

Area of Science:

  • Neuroscience
  • Bioengineering
  • Materials Science

Background:

  • Microelectrode arrays (MEAs) are crucial for studying neural activity, particularly retinal ganglion cells (RGCs).
  • Conventional planar MEAs suffer from poor electrode-RGC coupling, leading to low signal-to-noise ratio (SNR) and sensitivity.

Purpose of the Study:

  • To fabricate and characterize a novel 3D MEA platform for enhanced RGC recordings.
  • To investigate RGC encoding characteristics using multi-modal stimulation with the improved 3D MEA.

Main Methods:

  • Fabrication of a 3D MEA using photolithography and electroplating techniques.
  • Characterization of 3D MEA performance, including impedance, phase delay, charge storage capacity, and SNR.
  • Application of optical, electrical, and chemical stimulation to RGCs recorded with the 3D MEA.

Main Results:

  • The 3D MEA demonstrated significantly lower impedance and phase delay compared to planar MEAs.
  • The 3D MEA exhibited higher charge storage capacity and improved SNR.
  • Distinct RGC response patterns, firing rates, and temporal encoding variations were observed under different stimulation modalities, with electrical stimulation promoting firing and optical stimulation enhancing synchrony.

Conclusions:

  • The developed 3D MEA offers superior performance for RGC recording compared to traditional planar designs.
  • This technology facilitates a deeper understanding of neural encoding strategies in RGCs under diverse sensory inputs.
  • The findings pave the way for advancements in neural interface technologies and the study of visual processing.