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The Relationship Between Leptin Receptor Expression and Endometrial Carcinoma; A Case-Control Study
Mojtaba Sehhat1, Zahra Moshfegh Arani2, Niyusha Lajevardi Hosseini3
1Department of Social Medicine, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Iranian Journal of Pathology
|August 21, 2023
Summary
High leptin receptor (Ob-R) expression is significantly more common in endometrial carcinoma patients. This suggests leptin receptor could be a risk factor and potential biomarker for endometrial cancer screening and therapy.
Area of Science:
- Gynecologic Oncology
- Molecular Pathology
- Cancer Biomarkers
Background:
- Endometrial carcinoma is a prevalent malignancy in women globally and in Iran.
- Identifying causative factors is crucial for effective prevention, diagnosis, and treatment strategies.
- Leptin receptor (Ob-R) expression warrants investigation as a potential factor in endometrial carcinogenesis.
Purpose of the Study:
- To compare leptin receptor (Ob-R) expression levels between endometrial carcinoma and non-carcinoma tissue samples.
- To evaluate the association between Ob-R expression and endometrial cancer risk.
Main Methods:
- A case-control study involving 89 samples (45 carcinoma, 44 non-carcinoma).
- Immunohistochemistry was used to assess Ob-R expression (negative, positive, intensity).
- Statistical analyses included Chi-square, Fisher tests, and multivariate logistic regression, with significance set at P<0.05.
Main Results:
- Significantly higher frequency of high leptin receptor levels in endometrial carcinoma cases (57.8%) versus controls (2.3%).
- Positive Ob-R expression was associated with a 37.75-fold increased odds of endometrial carcinoma after adjusting for age, diabetes, and hypertension (P<0.001).
Conclusions:
- Leptin receptor may act as a risk factor for endometrial carcinoma in the studied population.
- Ob-R shows potential as a biomarker for endometrial cancer screening and therapeutic targeting.
