Measurement of Arterial Input Function in Hyperpolarized 13C Studies
Małgorzata Marjańska1, Thomas Z Teisseyre2,3, Nicholas W Halpern-Manners2,4
1Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6 ST SE, Minneapolis, Minnesota 55455, United States.
Applied Magnetic Resonance
|August 21, 2023
Summary
Measuring the input function of hyperpolarized [1-13C]pyruvate in vivo is crucial for metabolic modeling. This study shows the input function can be measured in a rat carotid artery using an implantable coil.
Area of Science:
- Biochemistry
- Medical Imaging
- Metabolic Research
Background:
- Dynamic nuclear polarization (DNP) enables hyperpolarized substrates for in vivo metabolism studies.
- Hyperpolarized [1-13C]pyruvate allows tracking of pyruvate and its metabolites (lactate, bicarbonate) in organs.
- Quantitative metabolic modeling requires measuring the substrate's input function, which is currently challenging.
Purpose of the Study:
- To develop and validate a method for measuring the in vivo input function of hyperpolarized [1-13C]pyruvate.
- To enable more accurate quantitative metabolic modeling of in vivo studies.
Main Methods:
- Utilized hyperpolarized [1-13C]pyruvate as the substrate.
- Employed an implantable coil for in vivo measurements.
- Measured the input function in the rat carotid artery.
Main Results:
- Successfully measured the in vivo input function of hyperpolarized [1-13C]pyruvate in the rat carotid artery.
- Demonstrated the feasibility of using an implantable coil for this measurement.
Conclusions:
- The developed method allows for non-invasive measurement of the hyperpolarized [1-13C]pyruvate input function.
- This advancement facilitates more accurate quantitative metabolic modeling in vivo.
- Improves the utility of hyperpolarized tracers for studying metabolism.
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