Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

Factors affecting Blood pressure

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:

Paracrine Signaling

Paracrine Signaling

Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...

Transducer Mechanism: Enzyme-Linked Receptors

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Role of SCF/c-KIT axis in pericyte TNT-guided vessel branching.

Fluids and barriers of the CNS·2026

Same author

Reviewer Comment on Pejhan et al. "Clinical Relevance, and Prognostic Significance of Isolated Angiitis of the Vasa Vasorum in Temporal Artery Biopsies".

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026

Same author

A novel pathogenic AIP variant associated with familial isolated pituitary adenoma.

Pituitary·2026

Same author

POLE-mutated endometrial carcinoma with extreme morphological and molecular heterogeneity: spatial clonal divergence in a multiple-classifier tumor.

Virchows Archiv : an international journal of pathology·2026

Same author

Medulloblastoma in Adolescents and Young Adults: Molecular Subgroups, Prognostic Biomarkers, and Age-Specific Therapeutic Challenges.

Current issues in molecular biology·2026

Same author

Sarcomatoid Renal Cell Carcinoma: Biological Features and Therapeutic Implications-A Narrative Review.

Current urology reports·2026

Search research articles

Related Experiment Video

Updated: Jul 18, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Bone angiocrine factors.

Domenico Ribatti¹, Antonio d'Amati¹

¹Department of Translational Biomedicine and Neurosciences, University of Bari Medical School, Bari, Italy.

Frontiers in Cell and Developmental Biology

|August 21, 2023

Summary

This summary is machine-generated.

Bone vascularization involves unique signals and factors. Understanding angiogenesis and osteogenesis crosstalk is key for bone health and developing new therapies for bone diseases.

Keywords:

FGF HIF1-α Notch VEGF angiocrine factors bone vascularization

More Related Videos

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Related Experiment Videos

Last Updated: Jul 18, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Area of Science:

Bone biology
Vascular biology
Skeletal development

Background:

Bones are highly vascularized tissues, formed via intramembranous or endochondral ossification.
Endochondral osteogenesis in long bones involves angiogenesis, where blood vessels invade a cartilage template.
Hypertrophic chondrocytes secrete angiogenic factors, initiating vascular invasion.

Purpose of the Study:

To explore the unique mechanisms of angiogenesis in bone.
To understand the crosstalk between angiogenesis and osteogenesis.
To identify molecular targets for bone therapies.

Main Methods:

Review of scientific literature on bone angiogenesis and osteogenesis.
Analysis of key signaling pathways involved, including VEGF, FGF, NOTCH, and HIF1-a.
Examination of the roles of osteogenic and endothelial cells in skeletal homeostasis.

Main Results:

Vascular endothelial growth factor (VEGF) is crucial for blood vessel invasion, cartilage remodeling, and ossification.
Fibroblast growth factors (FGFs) stimulate VEGFA and VEGFR-2 production, promoting chondrocyte growth.
NOTCH signaling regulates blood vessel formation, and HIF1-a promotes chondrocyte development via anaerobic metabolism.

Conclusions:

Angiogenesis and osteogenesis are intricately linked, essential for bone formation and homeostasis.
Bone endothelial cells and angiocrine factors play roles in skeletal remodeling, repair, and pathological conditions.
Understanding these mechanisms offers potential for novel therapeutic strategies targeting bone diseases.