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Pediatric heart failure with preserved ejection fraction, a review

Sophie Quennelle1,2,3, Damien Bonnet1,3

  • 1Pediatric Cardiology Department, Necker-Enfants Malades Hospital, Paris, France.

Frontiers in Pediatrics
|August 21, 2023
PubMed

Insights

Heart failure with preserved ejection fraction (HFpEF) is poorly understood in children. This review explores its causes, diagnosis challenges, and prognostic factors in pediatric patients.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Research

Background:

  • Diastolic dysfunction impairs heart filling, potentially causing heart failure even with normal systolic function.
  • Heart failure with preserved ejection fraction (HFpEF) is common in adults but underrecognized in children.

Purpose of the Study:

  • To review the causes and prognostic factors of HFpEF in children.
  • To discuss diagnostic challenges and provide a simplified diagnostic algorithm for pediatric HFpEF.

Main Methods:

  • Literature review focusing on pediatric HFpEF.
  • Analysis of underlying etiologies and associated pulmonary hypertension.
  • Examination of diagnostic difficulties and proposed solutions.

Main Results:

  • Causes of pediatric HFpEF are diverse and differ from adults.
  • Pulmonary hypertension profiles are associated with this condition.
  • Diagnosis in children presents unique challenges.

Conclusions:

  • Understanding pediatric HFpEF requires addressing its unique causes and diagnostic hurdles.
  • A simplified diagnostic algorithm can aid clinical practice.
  • Further research is needed to improve recognition and management of HFpEF in children.

Keywords:
cardiomyopathychilddiastolic heart failureheart failure with preserved ejection fractionpediatricpulmonary hypertension

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