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Bacteroides fragilis meningitis successfully treated with metronidazole after a previous failure with thiamphenicol
Journal of Clinical Microbiology
|September 1, 1986
Abstract:
A case of pyogenic meningitis caused by Bacteroides fragilis in a 72-year-old woman is reported. Although the isolate was susceptible to thiamphenicol, the patient did not respond to this drug. Metronidazole, which showed high bactericidal activity, was administered and achieved sterilization of the cerebrospinal fluid and complete clinical response.
Insights
A 72-year-old woman with pyogenic meningitis due to Bacteroides fragilis showed treatment failure with thiamphenicol. Metronidazole effectively treated the infection, sterilizing cerebrospinal fluid and leading to clinical recovery.
Area of Science:
- Neurology
- Infectious Diseases
- Microbiology
Background:
- Pyogenic meningitis can be caused by various bacteria.
- Bacteroides fragilis is an anaerobic bacterium that can cause serious infections.
Observation:
- A 72-year-old female presented with pyogenic meningitis.
- The causative agent was identified as Bacteroides fragilis.
Findings:
- The patient was initially treated with thiamphenicol, to which the isolate was susceptible, but showed no clinical improvement.
- Metronidazole administration resulted in sterilization of cerebrospinal fluid and a complete clinical response, demonstrating high bactericidal activity against Bacteroides fragilis.
Implications:
- This case highlights the importance of considering metronidazole for Bacteroides fragilis meningitis, especially in cases of treatment failure with other antibiotics.
- Metronidazole is a crucial therapeutic option for anaerobic bacterial meningitis.