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Migrasome, a novel organelle, differs from exosomes

Xun Tan1, Shujin He1,2, Fuling Wang3

  • 1Department of Pathology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272029, China.

Biochemistry and Biophysics Reports
|August 21, 2023
PubMed

Insights

Migrasomes and retractosomes are newly identified cellular vesicles involved in intercellular communication. This review details their formation, function, and distinctions from exosomes.

Area of Science:

  • Cell Biology
  • Extracellular Vesicles
  • Cellular Organelles

Background:

  • Migrasomes are organelles formed by migrating cells on retraction fibers.
  • Retractosomes are small extracellular vesicles derived from retraction fibers.
  • Both structures are involved in intercellular communication and cytoplasmic content release.

Purpose of the Study:

  • To provide an overview of migrasomes and retractosomes.
  • To discuss their discovery, biogenesis, distribution, and functions.
  • To differentiate them from exosomes.

Main Methods:

  • Literature review of existing research on migrasomes and retractosomes.
  • Comparative analysis of migrasomes, retractosomes, and exosomes.
  • Synthesis of current knowledge on their formation and roles.

Main Results:

  • Migrasomes and retractosomes are distinct vesicle types originating from retraction fibers.
  • They play roles in releasing cytoplasmic contents and mediating cell-cell communication.
  • Their formation mechanisms and specific functions require further investigation.

Conclusions:

  • Migrasomes and retractosomes represent significant discoveries in cell biology.
  • Understanding their biogenesis and function is crucial for advancing knowledge of intercellular signaling.
  • Further research is needed to fully elucidate their biological significance and therapeutic potential.
Keywords:
ExosomesMigrasomesOrganellesRetractosomesVesicles

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