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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
Published on: February 12, 2011
Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MR
Zheng Li1,2,3, Cheng Yan3,4, Guo-Xiang Hu3,4
1Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.
Insights
Layer-specific tissue tracking MRI reveals significant left ventricular myocardial deformation in cardiac amyloidosis (CA) patients. This technique effectively assesses cardiac involvement and predicts reduced ejection fraction in CA.
Area of Science:
- Cardiology
- Medical Imaging
- Biophysics
Background:
- Cardiac infiltration is a primary predictor of poor prognosis in systemic amyloidosis.
- Accurate evaluation of cardiac involvement is crucial for patient outcomes.
Purpose of the Study:
- To assess left ventricular myocardial deformation in cardiac amyloidosis (CA) using layer-specific tissue tracking MRI.
- To identify alterations in myocardial strain patterns specific to CA.
Main Methods:
- Layer-specific tissue tracking MRI was performed on 39 patients with CA and 39 healthy controls.
- Analysis focused on global and layer-specific strain parameters (GLS, GCS, GRS) from cine MRI sequences.
Main Results:
- Patients with CA exhibited significantly reduced whole-layer and layer-specific strain values compared to controls.
- Circumferential strain (GCS) demonstrated high diagnostic accuracy (AUC 0.995) for predicting reduced left ventricular ejection fraction (<40%) and was an independent predictor of systolic dysfunction.
Conclusions:
- Layer-specific tissue tracking MRI is a valuable tool for evaluating left ventricular myocardial deformation in cardiac amyloidosis.
- This method aids in the assessment of cardiac involvement and prediction of systolic dysfunction in CA patients.
Background:
Cardiac infiltration is the major predictor of poor prognosis in patients with systemic amyloidosis, thus it becomes of great importance to evaluate cardiac involvement.
Purpose:
We aimed to evaluate left ventricular myocardial deformation alteration in patients with cardiac amyloidosis (CA) using layer-specific tissue tracking MR.
Material And Methods:
Thirty-nine patients with CA were enrolled. Thirty-nine normal controls were also recruited. Layer-specific tissue tracking analysis was done based on cine MR images.
Results:
Compared with the control group, a significant reduction in LV whole layer strain values (GLS, GCS, and GRS) and layer-specific strain values was found in patients with CA (all P < 0.01). In addition, GRS and GLS, as well as subendocardial and subepicardial GLS, GRS, and GCS, were all diminished in patients with CA and reduced LVEF, when compared to those with preserved or mid-range LVEF (all P < 0.05). GCS showed the largest AUC (0.9952, P = 0.0001) with a sensitivity of 93.1% and specificity of 90% to predict reduced LVEF (<40%). Moreover, GCS was the only independent predictor of LV systolic dysfunction (Odds Ratio: 3.30, 95% CI:1.341-8.12, and P = 0.009).
Conclusion:
Layer-specific tissue tracking MR could be a useful method to assess left ventricular myocardial deformation in patients with CA.
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