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Updated: Jul 18, 2025
09:58
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
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E-box binding transcription factors in cancer
Yuanzhong Pan1, Pauline J van der Watt2,3, Steve A Kay1
1Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Frontiers in Oncology
|August 21, 2023
Summary
E-box-binding transcription factors (EBTFs) regulate genes and are crucial for cell function. This review explores their shared roles in development and cancer, highlighting therapeutic targets.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Biology
Background:
- E-boxes are key genomic regulatory elements.
- E-box-binding transcription factors (EBTFs) control gene transcription via helix-loop-helix or zinc finger domains.
- EBTFs are vital for development and cellular functions, with MYC being a well-known example in cancer.
Purpose of the Study:
- To provide a comprehensive analysis of EBTFs, focusing on their shared molecular principles in tumorigenesis.
- To review the structure, transcriptional regulation, physiological functions, and mutual regulation of EBTFs.
- To discuss the converging roles of EBTFs in cancer biology and their potential as therapeutic targets.
Main Methods:
- Literature review of EBTF structure and function.
- Analysis of shared regulatory mechanisms and physiological roles.
- Examination of EBTF involvement in cancer and drug development.
Main Results:
- EBTFs share common structural and functional features in regulating transcription.
- These factors play fundamental roles in both normal development and cellular physiology.
- Converging evidence points to EBTFs as critical players in tumorigenesis.
Conclusions:
- Understanding shared principles of EBTFs is crucial for deciphering their role in cancer.
- EBTFs represent a potential regulatory network for targeted cancer therapy.
- Recent advancements show promise in developing drugs targeting EBTFs for cancer treatment.
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