C-PEPTIDE AS AN INFLAMMATORY MARKER IN OBESE WOMEN.

Area of Science:

• Endocrinology
• Metabolic Health
• Inflammation Research

Background:

• Insulin resistance (IR) is a key factor in type 2 diabetes and metabolic syndrome.
• Chronic inflammation exacerbates insulin resistance.
• Neutrophil-to-lymphocyte ratio (NLR) is increasingly recognized as a marker of inflammation.

Purpose of the Study:

• To investigate the association between insulin resistance (IR) and NLR in obese women.
• To determine if NLR can serve as an indicator of inflammation in the context of IR in this population.

Main Methods:

• Analysis of homeostasis model assessment of IR (HOMA-IR), C-peptide, and NLR in 83 obese female patients.
• Bioelectrical impedance measurements were also performed.
• Statistical correlation analyses were conducted to assess relationships between parameters.

Main Results:

• A significant positive correlation was observed between fasting plasma C-peptide levels and NLR (r=0.36, p<0.003).
• C-peptide levels significantly influenced the increase in NLR (r2=0.31, p=0.002).
• Insulin levels did not show a similar significant effect on NLR (r2=0.01, p=0.544).

Conclusions:

• Plasma C-peptide levels demonstrate a stronger correlation with NLR than other IR parameters.
• C-peptide may function as a valuable laboratory marker for identifying IR and chronic inflammatory conditions in obese women.