Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

1.4K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.4K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

297
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
297

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the rationale for metronidazole use in dogs and cats.

The Journal of small animal practice·2025
Same author

Effectiveness of steam cleaning technology on reducing the occurrence of ESKAPE organisms and Escherichia coli in the stables of an equine referral hospital.

Journal of equine veterinary science·2025
Same author

The development, validation and application of an indirect enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to Streptococcus dysgalactiae subspecies dysgalactiae in lamb and ewe sera.

Research in veterinary science·2025
Same author

Adult brain neurogenesis does not account for behavioral differences between solitary and social bees.

Journal of insect physiology·2024
Same author

Dynamics of bla<sub>OXA-23</sub> gene transmission in Acinetobacter spp. from contaminated veterinary environmental surfaces: an emerging One Health threat?

The Journal of hospital infection·2024
Same author

A multinational survey of companion animal veterinary clinicians: How can antimicrobial stewardship guidelines be optimised for the target stakeholder?

Veterinary journal (London, England : 1997)·2023
Same journal

ANALYSIS OF SHORT-CHAIN FATTY ACIDS AND ASSOCIATION WITH GLUCAGON-LIKE PEPTIDE-1 IN HEALTHY, OBESE, PREDIABETES AND TYPE 2 DIABETES INDIVIDUALS.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same journal

ASSESSMENT OF NON-ENDOCRINOLOGIST PHYSICIANS' AWARENESS OF DIABETES TECHNOLOGIES: A NATIONWIDE SURVEY IN TURKEY.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same journal

LIPOHYPERTHROPHY: NEW TECHNOLOGY, OLD PROBLEMS.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same journal

EARLY REASSURANCE OR FALSE SAFETY? THE FETAL HOME DOPPLER USE IN ACTIVE MONITORING IN THE FIRST TRIMESTER OF PREGNANCY - FROM THE ENDOCRINE PERSPECTIVE.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same journal

LEVOTHYROXINE-SIMETHICONE DRUG INTERACTION AND PRESENCE OF MACRO-TSH IN AN INFANT WITH CONGENITAL HYPOTHYROIDISM.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same journal

DIAGNOSIS OF ACROMEGALY IN BILATERAL CARPAL TUNNEL SYNDROME AND FOLLOW-UP WITH ULTRASONOGRAPHY: A CASE REPORT.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
See all related articles

Related Experiment Video

Updated: Jul 18, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.6K

CENTRAL AND PERIPHERAL EFFECT OF MPTP VIA DOSE-DEPENDENT MAGNESIUM MODULATION.

R Lefter1, I M Balmus2, A Ciobica1,3,4

  • 1Centre of Biomedical Research, Romanian Academy, Iasi, Romania.

Acta Endocrinologica (Bucharest, Romania : 2005)
|August 21, 2023
PubMed
Summary
This summary is machine-generated.

MPTP causes constipation and behavioral changes in rats, which are worsened by low magnesium. Magnesium intake may mitigate these MPTP-induced effects, highlighting its role beyond the central nervous system.

Keywords:
MPTPParkinson’s diseaseanimal modelanxious behaviordepressive-like behaviorgastrointestinallocomotor impairment

More Related Videos

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model
05:38

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model

Published on: January 7, 2019

18.0K
Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
07:35

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess

Published on: June 1, 2022

2.3K

Related Experiment Videos

Last Updated: Jul 18, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.6K
Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model
05:38

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model

Published on: January 7, 2019

18.0K
Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
07:35

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess

Published on: June 1, 2022

2.3K

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Toxicology

Background:

  • MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) may induce gastrointestinal motility deficits and central nervous system (CNS) effects.
  • Magnesium's neuroprotective, gastrointestinal, and antioxidant roles suggest a potential interaction with MPTP-induced impairments.

Purpose of the Study:

  • To investigate the modulatory effects of varied magnesium intake on MPTP neurotoxicity.
  • To assess magnesium's impact on MPTP-induced functional gastrointestinal impairments.

Main Methods:

  • Rats received magnesium-controlled diets and enriched drinking water before MPTP administration.
  • Gastrointestinal motility, behavioral patterns (Y maze, elevated plus maze, open field, forced swim tests), and oxidative stress markers in brain and bowel were evaluated.

Main Results:

  • MPTP induced magnesium intake-dependent constipation, anxiety- and depressive-like behaviors, and altered pain tolerance.
  • Magnesium-dependent oxidative stress was observed in both brain and intestinal tissues.

Conclusions:

  • MPTP's systemic effects extend beyond the CNS to the gastrointestinal system.
  • Magnesium intake may play a crucial role in mitigating MPTP-induced abnormalities, suggesting its importance in managing neurotoxin-related conditions.