Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
The Thyroid Gland01:23

The Thyroid Gland

4.0K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.0K
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

9
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
9
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.6K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.6K
Factors Affecting Illness01:18

Factors Affecting Illness

4.3K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Injury Mechanics in Surfactant-Depleted and Healthy Rat Lungs: A Multi-scale Consideration of Artificial and Physiological Ventilation.

Annals of biomedical engineering·2026
Same author

Lung recruitment mechanics: coalescing tissue strains with organ expansion.

Respiratory research·2025
Same author

Fibrotic and emphysematous murine lung mechanics under negative-pressure ventilation.

American journal of physiology. Lung cellular and molecular physiology·2025
Same author

A Comparative Study of Ex-Vivo Murine Pulmonary Mechanics Under Positive- and Negative-Pressure Ventilation.

Annals of biomedical engineering·2023
Same author

Diseased and healthy murine local lung strains evaluated using digital image correlation.

Scientific reports·2023
Same author

Correction to: Examining lung mechanical strains as influenced by breathing volumes and rates using experimental digital image correlation.

Respiratory research·2022

Related Experiment Video

Updated: Jul 18, 2025

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

433

IMPACT OF COVID-19 ON THYROID FUNCTION: EVIDENCE FROM IRAN.

M Yadollahzadeh1, S Shakeri1, I Heydari2

  • 1Iran University of Medical Sciences, Firoozgar Medical and Educational Hospital, Department of Internal Medicine, Tehran, Iran.

Acta Endocrinologica (Bucharest, Romania : 2005)
|August 21, 2023
PubMed
Summary

COVID-19 severity correlates with thyroid dysfunction, particularly thyroid-stimulating hormone (TSH). Higher lactate dehydrogenase (LDH) levels in severe COVID-19 patients were linked to lower TSH, indicating a potential thyroid-inflammatory marker connection.

Keywords:
COVID-19InflammationIranThyroid function

More Related Videos

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

891
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.7K

Related Experiment Videos

Last Updated: Jul 18, 2025

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

433
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

891
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.7K

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Clinical Chemistry

Background:

  • COVID-19, a global pandemic, has been associated with various systemic complications.
  • Thyroid dysfunction is increasingly recognized as a potential complication in viral infections.
  • Understanding the interplay between COVID-19 severity, thyroid hormones, and inflammation is crucial for patient management.

Purpose of the Study:

  • To investigate the association between COVID-19 severity and thyroid function.
  • To explore the relationship between thyroid hormones and inflammatory markers in COVID-19 patients.

Main Methods:

  • An observational study involving 95 COVID-19 patients.
  • Measurement of thyroid-stimulating hormone (TSH), thyroxine, triiodothyronine, C-reactive protein, erythrocyte sedimentation rate, lactate dehydrogenase (LDH), and lymphocytes.
  • Statistical analysis using t-tests, nonparametric tests, and Spearman correlation.

Main Results:

  • Increasing trends of thyroid dysfunction, notably TSH, were observed with progressing COVID-19 severity, though not statistically significant.
  • A significant inverse Spearman correlation (r=-0.28) was found between TSH and LDH.
  • A direct association was confirmed between COVID-19 severity and LDH levels (p<0.001).

Conclusions:

  • A direct relationship exists between COVID-19 severity and LDH levels.
  • A reverse association was observed between LDH levels and TSH, suggesting a link between inflammation and thyroid function in COVID-19.