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Updated: Jul 18, 2025
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Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
Published on: January 31, 2022
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SIMULTANEOUS INTAKE OF LIQUID L-T4 FORMULATION AND IRON SALT: FACT OR FICTION?
V Maltese1, E Gatta1, P Facondo1
1University of Brescia, Azienda Socio-Sanitaria Territoriale (ASST) Spedali Civili di Brescia, SSD Endocrinologia, Department of Clinical and Experimental Sciences, Brescia, Italy.
Acta Endocrinologica (Bucharest, Romania : 2005)
|August 21, 2023
Summary
Iron supplements can reduce levothyroxine (L-T4) absorption in tablet form. However, liquid L-T4 formulations allow co-ingestion with iron salts without affecting absorption.
Area of Science:
- Endocrinology
- Pharmacology
- Nutritional Science
Background:
- Hypothyroidism and iron deficiency are highly prevalent global health issues.
- Many patients require both levothyroxine (L-T4) for hypothyroidism and iron supplements for iron deficiency.
Purpose of the Study:
- To assess the impact of iron salt consumption on levothyroxine (L-T4) absorption.
- To compare these effects across various L-T4 formulations.
Main Methods:
- Comprehensive literature search of PubMed/MEDLINE, Web of Science, and Scopus databases.
- Inclusion of original studies and reviews published in English up to December 2022.
- Selection based on relevance to the interaction between iron salts and L-T4 formulations.
Main Results:
- Iron salt intake significantly impairs the absorption of levothyroxine (L-T4) when administered in tablet form.
- Newer L-T4 formulations appear to mitigate or eliminate this absorption interference.
Conclusions:
- Liquid L-T4 formulations can be taken with iron salts without compromising L-T4 absorption.
- Further research is needed to validate these findings for soft-gel capsule L-T4 formulations.
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