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Related Concept Videos

Fatigue01:21

Fatigue

206
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
206
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

2.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.6K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

1.0K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Updated: Jul 18, 2025

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
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Thoughts on Fatigue in Multiple Sclerosis Patients.

Daphne Bakalidou1, Vasileios Giannopapas2,3, Sotirios Giannopoulos3

  • 1Laboratory of Neuromuscular and Cardiovascular Study of Motion (LANECASM) Physiotherapy Department, Faculty of Health and Care Sciences, University of West Attica, Athens, GRC.

Cureus
|August 21, 2023
PubMed
Summary

Environmental temperature significantly impacts chronic fatigue in people with multiple sclerosis (PwMS). Further research is needed to fully understand temperature

Keywords:
fatiguefatigue scalesheat sensitivitymultiple sclerosistemperatureuhthoff's phenomenon

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Area of Science:

  • Neurology
  • Environmental Medicine

Background:

  • Chronic fatigue is a prevalent and debilitating symptom for people with multiple sclerosis (PwMS).
  • Fatigue in PwMS manifests as reversible motor and cognitive impairment, often accompanied by reduced motivation and a need for rest.
  • Fatigue exacerbation can be triggered by various factors including physical/mental activity, environmental conditions, infections, and diet.

Discussion:

  • While heat's effect on fatigue is recognized, the specific influence of ambient temperature and relative humidity on PwMS requires more systematic investigation.
  • This article synthesizes current literature and clinical insights to explore the relationship between environmental temperature and fatigue symptomatology in multiple sclerosis.

Key Insights:

  • Environmental temperature is a critical, yet under-researched, factor in the manifestation of chronic fatigue in people with multiple sclerosis.
  • Understanding the precise role of temperature fluctuations is essential for managing fatigue symptoms in PwMS.

Outlook:

  • Further systematic studies are necessary to elucidate the complex interplay between environmental temperature and multiple sclerosis-related fatigue.
  • Developing targeted interventions based on environmental factors could improve quality of life for PwMS experiencing fatigue.