Related Experiment Video
Updated: Jul 18, 2025

A Proximal Culture Method to Study Paracrine Signaling Between Cells
Published on: August 28, 2018
Emerging role of exosome-derived non-coding RNAs in tumor-associated angiogenesis of tumor microenvironment
Sai-Li Duan1,2, Wei-Jie Fu2, Ying-Ke Jiang1
1Department of General Surgery, Xiangya Hospital Central South University, Changsha, China.
Abstract:
The tumor microenvironment (TME) is an intricate ecosystem that is actively involved in various stages of cancer occurrence and development. Some characteristics of tumor biological behavior, such as proliferation, migration, invasion, inhibition of apoptosis, immune escape, angiogenesis, and metabolic reprogramming, are affected by TME. Studies have shown that non-coding RNAs, especially long-chain non-coding RNAs and microRNAs in cancer-derived exosomes, facilitate intercellular communication as a mechanism for regulating angiogenesis. They stimulate tumor growth, as well as angiogenesis, metastasis, and reprogramming of the TME. Exploring the relationship between exogenous non-coding RNAs and tumor-associated endothelial cells, as well as their role in angiogenesis, clinicians will gain new insights into treatment as a result.
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
lncRNA - Long Non-coding RNAs
The Tumor Microenvironment
Mechanism of Angiogenesis
Overview of Exosomes
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

