Targeting mitochondrial dynamics proteins for the treatment of doxorubicin-induced cardiotoxicity

Rui Chen1, Mengwen Niu2, Xin Hu1

  • 1Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China.

PubMed

Insights

Mitochondrial dynamics are key in doxorubicin (DOX) cardiotoxicity. Targeting proteins like DRP1 and MFN2 may protect the heart without reducing cancer treatment effectiveness.

Area of Science:

  • Biochemistry
  • Cardiology
  • Oncology

Background:

  • Doxorubicin (DOX) is a vital chemotherapy drug with dose-limiting cardiotoxicity.
  • Mitochondria are primary targets of DOX-induced cardiac damage.
  • Impaired mitochondrial dynamics (fission/fusion imbalance) contribute to DOX cardiotoxicity.

Purpose of the Study:

  • To review mitochondrial dynamics in DOX cardiotoxicity.
  • To explore therapeutic strategies targeting mitochondrial dynamics for DOX-induced cardiac injury.
  • To assess if these strategies impact anticancer efficacy.

Main Methods:

  • Literature review of studies on DOX cardiotoxicity and mitochondrial dynamics.
  • Analysis of research on targeting mitochondrial dynamics proteins (e.g., DRP1, MFN2).
  • Evaluation of interventions for DOX-induced cardiac damage.

Main Results:

  • DOX disrupts mitochondrial dynamics, leading to ROS overproduction, metabolic dysfunction, and apoptosis.
  • Targeting mitochondrial dynamics proteins shows promise in mitigating DOX cardiotoxicity.
  • These interventions may preserve or even enhance DOX's anticancer effects.

Conclusions:

  • Mitochondrial dynamics are a critical factor in DOX cardiotoxicity.
  • Targeting mitochondrial dynamics offers a potential strategy to reduce cardiac side effects of DOX.
  • Further research into these targets could lead to safer and more effective chemotherapy.

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