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Related Experiment Videos

Autointoxication revisited.

J R Person, J D Bernhard

    Journal of the American Academy of Dermatology
    |September 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Gastrointestinal issues may cause skin conditions like pustular dermatitis and inflammatory bowel disease. This is potentially due to immune complexes from gut microbes, suggesting a shared origin for various inflammatory diseases.

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    Area of Science:

    • Immunodermatology
    • Gastroenterology
    • Rheumatology

    Background:

    • Pustular dermatitis and inflammatory bowel disease (IBD) are linked to gut microbial antigen absorption.
    • Monomeric serum IgA, originating in the GI tract, and circulating IgA immune complexes are implicated.
    • Dermatitis herpetiformis serves as an example of IgA immune complex-related conditions with a potential GI source.

    Purpose of the Study:

    • To explore the common pathogenesis of various inflammatory conditions linked to the gastrointestinal tract.
    • To investigate the role of microbial antigen absorption and IgA immune complexes in these diseases.

    Main Methods:

    • The study reviews existing literature and clinical observations.
    • It analyzes the proposed mechanisms involving mucosal permeability and IgA function.

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  • It considers the association between specific conditions and potential GI tract origins.

    • Main Results:

    • Circulating IgA immune complexes and elevated serum IgA may result from altered mucosal permeability.
    • Failure of locally produced dimeric IgA to neutralize antigens could contribute.
    • A common pathogenesis is proposed for conditions including Reiter's syndrome, psoriasis, pyoderma gangrenosum, ankylosing spondylitis, Behçet's syndrome, pustular psoriasis, and lithium-induced eruptions.

    Conclusions:

    • A shared gastrointestinal-related pathogenesis is hypothesized for a spectrum of seemingly unrelated inflammatory diseases.
    • Alterations in gut barrier function and immune response may underlie these conditions.
    • Further research into the gut-skin-joint axis is warranted.