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Updated: Jul 18, 2025

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
Published on: January 20, 2023
Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome
Fuki M Hisama1, Renuka Kandhaya Pillai2, Julia Sidorova2
1Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, USA.
Abstract:
A progeroid family was found to harbor a pathogenic variant in the CASP5 gene that encodes inflammatory caspase 5. Caspase 5-depleted fibroblasts exhibited hyper-activation of inflammatory cytokines in response to pro-inflammatory stimuli. Long-term intermittent hyper-inflammatory response is likely the cause of the accelerated aging phenotype comprised of earlier onset of common aging diseases, supporting inflammaging as a potential common disease mechanism of progeroid syndromes and possibly normative aging.
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