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Updated: Jul 18, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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C5a-C5aR1 induces endoplasmic reticulum stress to accelerate vascular calcification via PERK-eIF2α-ATF4-CREB3L1

Aiting Liu1, Zhenwei Chen2, Xiaoxue Li1

  • 1Department of Cardiology, Joint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic Diseases, The Eighth Affiliated Hospital of Sun Yat-sen University, Shennan Middle Rd, Shenzhen, 518000, China.

Cardiovascular Research
|August 21, 2023
PubMed
Abstract

Keywords:
C5a-C5aR1CREB3L1Endoplasmic reticulum stressPERK-eIF2α-ATF4 pathwayVascular calcification

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