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Updated: Jul 18, 2025
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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
17.4K
Maintaining brain health across the lifespan
Isabel García-García1, Olga Donica2, Armand Aaron Cohen3
1Laboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Centre for Research in Neurosciences, Lausanne University Hospital, University of Lausanne, Switzerland; Clinique la Prairie, Montreux, Switzerland.
Neuroscience and Biobehavioral Reviews
|August 21, 2023
Summary
Healthy aging depends on managing lifetime factors impacting the body and brain. Interventions targeting diet, exercise, sleep, and inflammation can promote healthy brain aging and preserve function in older adults.
Area of Science:
- Neuroscience
- Gerontology
- Public Health
Background:
- Aging trajectories vary significantly, from frailty to preserved function.
- Understanding lifetime factors influencing aging is crucial for developing interventions.
- Brain health in old age is influenced by numerous external and internal factors.
Purpose of the Study:
- To provide a comprehensive literature overview on lifetime factors affecting brain health.
- To explore the mechanisms and interactions of risk factors on aging.
- To discuss current strategies for mitigating these risk factors.
Main Methods:
- Literature review of studies on aging, brain health, and risk factors.
- Analysis of cumulative and gradual effects of lifestyle and health factors.
- Synthesis of evidence on interventions for healthy aging.
Main Results:
- Unhealthy diet, sedentary behavior, sleep issues, cardiovascular risks, and inflammation cumulatively harm brain health.
- These factors interact, influencing physical, cognitive, and social functions in aging.
- Timely interventions can counteract risk factors and promote successful aging.
Conclusions:
- Modifiable risk factors significantly impact brain health across the lifespan.
- Personalized, multi-domain strategies are key for brain health maintenance.
- Insights into risk factors can inform interventions for an aging population.
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