Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

2.0K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.0K
Cancer Prevention02:59

Cancer Prevention

6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.2K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial intelligence in multi-omics analysis of heart diseases.

Progress in molecular biology and translational science·2026
Same author

Therapeutic Insights into Natural Products for Modulating Neurodegenerative Disease Pathways.

Central nervous system agents in medicinal chemistry·2026
Same author

Development and optimization of a novel spectroscopic method to monitor crystallization behavior of BCS-II drug.

Turkish journal of chemistry·2026
Same author

Integrative transcriptome and genome resequencing reveals conserved flowering regulators and allelic variants in early- and late-flowering linseed (Linum usitatissimum L.) accessions.

Scientific reports·2026
Same author

Phase-Synergized NiS-MnS-MoS<sub><b>2</b></sub> Hybrid: An Efficient and Durable Electrocatalyst for Alkaline Urea Oxidation Reaction.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Unique nano-granular ZnCo<sub>2</sub>O<sub>4</sub> microplate-decorated Pt/C as an efficient electrocatalyst for methanol electrooxidation.

Nanoscale·2026

Related Experiment Video

Updated: Jul 18, 2025

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

8.5K

Chebulinic Acid: An Incipient Anticancer Agent.

Aashima1, Mehak Rathi1, Shilpi1

  • 1Department of Pharmaceutical Sciences, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, 135001, Haryana, India.

Recent Patents on Anti-Cancer Drug Discovery
|August 22, 2023
PubMed
Summary

Terminalia chebula and its active compound chebulinic acid show significant anticancer potential. Ongoing clinical trials and novel delivery systems aim to validate their therapeutic applications against various cancers.

Keywords:
Anti-cancerTerminalia chebulachebulinic acidextractionpatentstherapy.

More Related Videos

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NF&#954;B Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

12.3K
Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells
11:06

Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells

Published on: May 20, 2015

28.7K

Related Experiment Videos

Last Updated: Jul 18, 2025

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

8.5K
Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NF&#954;B Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

12.3K
Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells
11:06

Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells

Published on: May 20, 2015

28.7K

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Drug Discovery

Background:

  • Terminalia chebula (T. chebula) is a medicinal plant with chebulinic acid as its primary active constituent.
  • T. chebula and chebulinic acid possess a wide range of therapeutic properties, including antimicrobial, antioxidant, and anti-inflammatory effects.

Purpose of the Study:

  • To review recent literature and patents on T. chebula and chebulinic acid.
  • To explore their isolation, extraction, and application in cancer prevention and other diseases.

Main Methods:

  • Literature and patent review focusing on anti-cancer potential.
  • Analysis of scientific novelty and impact of T. chebula and chebulinic acid research.

Main Results:

  • Both T. chebula and chebulinic acid are under investigation for anticancer properties in vitro and in vivo.
  • Novel extraction techniques and drug delivery systems are being developed to enhance bioavailability.
  • Clinical trials are underway to evaluate various therapeutic potentials.

Conclusions:

  • Promising clinical trials suggest T. chebula and chebulinic acid could offer new cancer treatment interventions.
  • Further clinical validation alongside standard therapies is necessary to establish their full therapeutic potential.