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Related Experiment Video

Updated: Jul 18, 2025

Analysis of Coronary Vessels in Cleared Embryonic Hearts

Analysis of Coronary Vessels in Cleared Embryonic Hearts

Published on: December 7, 2016

Coronary artery established through amniote evolution.

Kaoru Mizukami¹, Hiroki Higashiyama¹, Yuichiro Arima^1,2

¹Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

|August 22, 2023

Summary

This summary is machine-generated.

Amniote coronary arteries evolved from transient embryonic vessels, unlike amphibians and fish which retain ancestral structures. This significant evolutionary shift in heart vasculature occurred during tetrapod evolution.

Keywords:

anatomy cardiovascular developmental biology evo-devo evolutionary biology heart morphology mouse xenopus zebrafish

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Analysis of Coronary Vessels in Cleared Embryonic Hearts

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Area of Science:

Evolutionary biology
Comparative anatomy
Cardiovascular development

Background:

Coronary arteries are vital for heart function in humans, but some fish species survive without them.
This suggests evolutionary adaptations in coronary vasculature within the tetrapod lineage.

Purpose of the Study:

To investigate the evolutionary origin of true ventricular coronary arteries in amniotes.
To compare coronary vasculature development across different vertebrate groups.

Main Methods:

Comparative developmental analysis of coronary artery formation in mouse and quail embryos.
Examination of coronary vasculature in amphibians, zebrafish, and chondrichthyans.

Main Results:

Amniote coronary arteries develop from transient vascular plexuses (aortic subepicardial vessels and primitive coronary plexus).
Amphibians retain ASV-like vessels as truncal coronary arteries and lack a primitive coronary plexus.
Zebrafish and chondrichthyans possess ASV-like hypobranchial arteries as their primary coronary supply.

Conclusions:

The ventricular coronary artery in adult amniotes is a novel structure resulting from a new remodeling process.
Transient aortic subepicardial vessels in amniote embryos represent remnants of ancestral coronary vessels.
Evolutionary modifications of branchial arteries likely accompanied the physiological transition during amniote evolution.