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Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

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Published on: October 18, 2011

A Case Report of Kearns-Sayre Syndrome: Not an Absolute Contraindication for Radiotherapy.

Shaun Z Yap¹, Abdul Rahim Mohd Tahir¹, Thomas P Shakespeare¹

¹Radiation Oncology, Mid North Coast Cancer Institute Coffs Harbour, New South Wales, AUS.

|August 22, 2023

Summary

Radiotherapy may be safe for patients with Kearns-Sayre syndrome (KSS), a rare mitochondrial disorder. A KSS patient with basal cell carcinoma showed a complete tumor response to radiotherapy with no adverse effects, suggesting potential safety for this population.

Keywords:

cm (cutaneous melanoma) bcc (basal cell carcinoma) scc (squamous cell carcinoma)general radiation oncology mitochondrial dna mutation radiation response radiation side effects vmat radiotherapy

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Area of Science:

Oncology
Mitochondrial Medicine
Radiation Oncology

Background:

Kearns-Sayre syndrome (KSS) is a rare mitochondrial DNA depletion disorder.
The safety and efficacy of radiotherapy in KSS patients are not well-established.
Basal cell carcinoma is a common skin cancer, but its treatment in rare genetic disorders requires careful consideration.

Observation:

A 60-year-old male diagnosed with KSS also had locally advanced basal cell carcinoma.
The patient received radiotherapy with curative intent as the sole treatment modality.
Treatment was well-tolerated, with no significant acute or late toxicities observed.

Findings:

The patient achieved a complete clinical and radiological response to radiotherapy.
No tumor recurrence was observed 2.5 years post-treatment.
This case suggests radiotherapy may be a viable treatment option for basal cell carcinoma in KSS patients.

Implications:

Radiotherapy could be considered for treating malignancies in patients with KSS.
Further research is warranted to investigate the effects of ionizing radiation on individuals with mitochondrial DNA defects.
This case contributes to understanding the oncological treatment possibilities for rare mitochondrial disorders.