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Methicillin-resistant Staphylococcus aureus-induced staphylococcal scalded skin syndrome in a preterm infant, and

Ryo Fukaura1, Chiaki Terashima-Murase1, Mai Ota1

  • 1Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

The Journal of Dermatology
|August 22, 2023
PubMed
Abstract

No abstract available in PubMed .

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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

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