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Related Experiment Video

Updated: Jul 18, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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Animal models in systemic sclerosis: an update.

Xiongjie Bi1,2, Tingting Mills3, Minghua Wu1

  • 1Division of Rheumatology, Department of Internal Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.

Current Opinion in Rheumatology
|August 22, 2023
PubMed
Summary

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Assessment of skin stiffness in systemic sclerosis using optical coherence elastography: A comparative study with histology and clinical parameters.

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Animal models are crucial for understanding systemic sclerosis (SSc) pathogenesis. This review highlights recent models and pathways, aiding the development of SSc treatments.

Area of Science:

  • Rheumatology and Immunology
  • Translational Medicine
  • Fibrotic Diseases

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease marked by inflammation and fibrosis.
  • Understanding SSc pathogenesis is key to developing effective therapies.
  • Animal models are vital for studying disease mechanisms.

Approach:

  • This review provides an updated overview of current SSc animal models.
  • Focuses on novel pathways and genetic technologies in recent models.
  • Investigates pathways like type I interferon signaling, immune cell function, and pulmonary artery hypertension (PAH).

Key Points:

  • No single model fully replicates SSc; a combination offers comprehensive insights.
  • Recent models explore early type I interferon signaling.

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  • Immune cell function and PAH are key areas of investigation.

    • Conclusions:

    • Animal models are indispensable preclinical tools for SSc research.
    • Insights from diverse models accelerate the development of SSc therapeutics.
    • Further research using these models can lead to effective SSc treatments.