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Positive association between alkaline phosphatase and arteriosclerosis: a cross-sectional study
Yaqing Zhou1, Chen Chen2, Long Bai3
1Department of Physical Examination Center, The Second Hospital of Hebei Medical University, Shijiazhuang.
Journal of Cardiovascular Medicine (Hagerstown, Md.)
|August 22, 2023
Summary
Serum alkaline phosphatase (ALP) is positively linked to early arteriosclerosis, with risk plateauing above 135 U/l. This association was not significant in individuals with diabetes.
Area of Science:
- Cardiovascular Health
- Biochemistry
- Vascular Biology
Background:
- Serum alkaline phosphatase (ALP) is implicated in cardiovascular events and cerebral arteriosclerosis.
- The specific relationship between ALP and the development of early arteriosclerosis requires further investigation.
Purpose of the Study:
- To examine the association between serum ALP levels and early arteriosclerosis.
- To assess early arteriosclerosis using brachial-ankle pulse wave velocity (Ba-PWV).
Main Methods:
- A retrospective analysis of 5011 participants undergoing health examinations.
- Utilized regression analysis, generalized additive models (GAM) with smoothing functions, threshold effect analysis, and subgroup analyses.
- Measured serum ALP and Ba-PWV in participants from 2012 to 2017.
Main Results:
- A significant positive association was found between serum ALP and arteriosclerosis (OR=1.008, P<0.001).
- A two-stage association was observed, with a saturation effect beyond 135 U/l.
- The positive association was not evident in participants with diabetes (OR=0.996, P=0.690).
Conclusions:
- Serum ALP levels are positively associated with early arteriosclerosis, exhibiting a saturation effect at levels above 135 U/l.
- The link between ALP and arteriosclerosis is unclear in diabetic individuals.
- Brachial-ankle pulse wave velocity (Ba-PWV) positively correlated with arteriosclerosis in both groups.
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