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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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The burden of calcific aortic stenosis: what's behind?

S Romiti1, M Vinciguerra, M D'Abramo

  • 1Department of Clinical, Internal Medicine, Anaesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy. silvia.romiti@uniroma1.it.

European Review for Medical and Pharmacological Sciences
|August 22, 2023
PubMed

Insights

Calcific aortic valve stenosis (CAS) is a common cardiovascular disease with no effective medical treatments. This review explores CAS pathogenesis and potential new therapeutic targets for this growing condition.

Area of Science:

  • Cardiovascular Medicine
  • Pathophysiology
  • Pharmacology

Background:

  • Calcific aortic valve stenosis (CAS) is a leading cause of cardiovascular disease (CVD) death in Western countries.
  • CAS prevalence increases with age, and current guidelines lack treatments to prevent its development or slow progression.
  • The aging population and limited medical options suggest a doubling or tripling of CAS cases in coming decades.

Conclusions:

  • CAS is a significant and growing public health concern.
  • Understanding CAS pathogenesis is crucial for developing effective treatments.
  • Novel therapeutic targets offer hope for managing and potentially preventing CAS progression.

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