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Comparison of clopidogrel vs. ticagrelor medication adherence in patients with acute coronary syndrome

O Dogan1, Z Bulat, A Yildiz

  • 1Department of Cardiology, Istinye State Hospital, Ministry of Health, Istanbul, Turkey. omrdgn123@gmail.com.

European Review for Medical and Pharmacological Sciences
|August 22, 2023
PubMed

Insights

Medication adherence to dual antiplatelet therapy was similar for clopidogrel and ticagrelor post-acute coronary syndrome. Higher education and percutaneous coronary intervention predicted better adherence.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Medication nonadherence to dual antiplatelet therapy (DAPT) is linked to increased major cardiovascular events.
  • Effective DAPT is crucial for patients following acute coronary syndrome (ACS).

Purpose of the Study:

  • To investigate medication adherence to clopidogrel and ticagrelor over 12 months in patients post-ACS.
  • To identify factors influencing medication adherence in this patient population.

Main Methods:

  • A study involving 509 patients receiving DAPT for one year post-ACS.
  • Medication adherence assessed using the proportion of days covered (PDC) > 80% via pharmacy data.

Main Results:

  • No significant difference in medication adherence between clopidogrel (68.3%) and ticagrelor (64.6%) groups.
  • Higher education levels and percutaneous coronary intervention (PCI) independently predicted adherence.

Conclusions:

  • Medication adherence rates were comparable for clopidogrel and ticagrelor in ACS patients.
  • Higher education and PCI as revascularization are key predictors of DAPT adherence.
Abstract

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