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The 2022 FASEB Virtual Catalyst Conference on the Cardiac Interatrial Septum and Stroke Risk, December 7, 2022
Jonathan Schilling1, Jeannette P Lin2, Sunil V Mankad3
1Department of Medicine, University of California, Irvine, California, USA.
Summary
The cardiac interatrial septum can be a source of stroke. This review covers diagnosis and treatment for stroke patients with cardiac interatrial septum variations, including patent foramen ovale and septal pouches.
Area of Science:
- Cardiology and Neurology
- Focus on the cardiac interatrial septum's role in stroke etiology.
Background:
- Emerging evidence links the cardiac interatrial septum to thromboembolic stroke.
- Lack of consensus exists regarding treatment for stroke patients with interatrial septum variations.
Purpose of the Study:
- To summarize background, diagnostic, and treatment considerations for stroke patients with cardiac interatrial septum pathologies.
- To present key discussions from the FASEB Virtual Catalytic Conference on Cardiac Interatrial Septum and Stroke Risk.
Main Methods:
- Review of embryogenesis, anatomic variants (e.g., patent foramen ovale, left atrial septal pouch), and shunting physiologies.
- Discussion of imaging modalities including echocardiography, CT, and MRI.
- Expert debate on treatment options (anticoagulation, closure) and risk factors.
Main Results:
- Detailed exploration of cardiac interatrial septum embryogenesis and common anatomic variants.
- Analysis of injury mechanisms and consequences of interatrial septum abnormalities.
- Evaluation of diagnostic imaging and therapeutic strategies for stroke prevention.
Conclusions:
- The cardiac interatrial septum is a significant factor in stroke risk, necessitating tailored diagnostic and treatment approaches.
- Further research and expert consensus are crucial for managing patients with interatrial septum variations and a history of stroke.
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