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Updated: Jul 18, 2025

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
Published on: November 23, 2019
Musculoskeletal CT Imaging: State-of-the-Art Advancements and Future Directions
Shadpour Demehri1, Francis I Baffour1, Joshua G Klein1
1From the Russell H. Morgan Department of Radiology and Radiological Science (S.D., J.G.K., E.G., H.A.I., K.M., K.T., E.K.F.) and Department of Biomedical Engineering (W.B.Z.), Johns Hopkins University School of Medicine, 601 N Carolina St, Baltimore, MD 21287; Division of Musculoskeletal Imaging, Department of Radiology, Mayo Clinic, Rochester, Minn (F.I.B.); Department of Radiology, New York University Grossman School of Medicine, New York, NY (J.F.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); and Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, Mass (A.G.).
Abstract:
CT is one of the most widely used modalities for musculoskeletal imaging. Recent advancements in the field include the introduction of four-dimensional CT, which captures a CT image during motion; cone-beam CT, which uses flat-panel detectors to capture the lower extremities in weight-bearing mode; and dual-energy CT, which operates at two different x-ray potentials to improve the contrast resolution to facilitate the assessment of tissue material compositions such as tophaceous gout deposits and bone marrow edema. Most recently, photon-counting CT (PCCT) has been introduced. PCCT is a technique that uses photon-counting detectors to produce an image with higher spatial and contrast resolution than conventional multidetector CT systems. In addition, postprocessing techniques such as three-dimensional printing and cinematic rendering have used CT data to improve the generation of both physical and digital anatomic models. Last, advancements in the application of artificial intelligence to CT imaging have enabled the automatic evaluation of musculoskeletal pathologies. In this review, the authors discuss the current state of the above CT technologies, their respective advantages and disadvantages, and their projected future directions for various musculoskeletal applications.
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