Low Blood Glucose Index Associated with Cardiovascular Events in Diabetic Hemodialysis Patients

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Ruibin He1, Yingli Xuan2, Lingling Zhu3

  • 1The Baoshan Branch of Renji Hospital, Department of Nephrology, Shanghai Jiao Tong University, School of Medicine, Shanghai, China, hrb-03@163.com.

Blood Purification
|August 22, 2023
PubMed

Insights

High low blood glucose index (LBGI) in diabetic hemodialysis patients significantly increases cardiovascular event risk. Glycemic variability, particularly LBGI, is linked to adverse outcomes and albumin levels in these patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiology

Background:

  • Diabetic kidney disease (DKD) management requires careful blood glucose monitoring.
  • Glycemic variability's impact on cardiovascular disease (CVD) events in DKD patients on hemodialysis is understudied.
  • Understanding these associations is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate glycemic variability and its association with 1-year cardiovascular disease events in diabetic hemodialysis patients.
  • To explore the relationship between glycemic variability and blood biochemical indicators in this population.

Main Methods:

  • A cohort of 27 diabetic hemodialysis patients was analyzed.
  • Continuous glucose monitoring (CGM) assessed glucose variability over 14 days.
  • Patients were grouped by Time in Range (TIR >70% or ≤70%); 1-year cardiovascular events (3P MACE) were recorded.

Main Results:

  • Higher low blood glucose index (LBGI) was significantly associated with an increased risk of 3P MACE (HR = 2.37, p = 0.018).
  • Albumin levels showed a positive association with LBGI (β = 0.51, p = 0.036).
  • Other CGM parameters correlated with plasma levels of albumin, glycosylated hemoglobin, and hemoglobin.

Conclusions:

  • Elevated LBGI over 14 days is a significant predictor of cardiovascular events in diabetic hemodialysis patients.
  • Glycemic variability metrics, like LBGI, are linked to biochemical markers and adverse cardiovascular outcomes.
Abstract

Keywords:
Cardiovascular diseaseContinuous glucose monitoringDiabetic kidney diseaseGlycemic variabilityHemodialysis

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