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Evaluating fine changes in visual function of diabetic eyes using spatial-sweep steady-state pattern

Norihiro Nagai1,2, Yasuaki Mushiga1,2, Yoko Ozawa3,4,5

  • 1Department of Ophthalmology, St. Luke's International Hospital, Tokyo, Japan.

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|August 22, 2023
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Summary

Spatial-sweep steady-state pattern electroretinography (swpPERG) effectively detects subtle visual function declines in diabetic eyes, even before diabetic retinopathy (DR) is evident. This method shows promise for early detection and monitoring of diabetic eye disease.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Diabetic eye disease affects visual function.
  • Early detection of visual changes is crucial for managing diabetic complications.
  • Current methods may not detect subtle visual function impairments.

Purpose of the Study:

  • To evaluate spatial-sweep steady-state pattern electroretinography (swpPERG) as a sensitive method for assessing visual function in diabetic eyes.
  • To correlate swpPERG results with inner retinal structural changes.

Main Methods:

  • Assessed visual function using swpPERG in control, diabetic without DR, and diabetic with DR eyes.
  • Analyzed signal-to-noise ratios (SNRs) using Fourier transform.
  • Correlated SNRs with optical coherence tomography (OCT) and OCT angiography (OCTA) measurements.

Main Results:

  • Diabetic eyes (with and without DR) showed lower swpPERG SNRs than controls.
  • Diabetic eyes with DR had lower SNRs than those without DR.
  • SNRs correlated significantly with ganglion cell layer volume and foveal vascular density.

Conclusions:

  • swpPERG is a sensitive technique for detecting early visual function loss in diabetic eyes.
  • swpPERG results correlate with inner retinal structural integrity.
  • swpPERG may aid in monitoring diabetic eye disease progression.